CPSF7 Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF7 activates directly the mRNA 3'-processing machinery. Binds to pA signals in RNA substrates. Belongs to the RRM CPSF6/7 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA splicing; RNA-binding
Chromosomal Location of human Ortholog: 11q12.2
Cellular Component:  cytoplasm; mRNA cleavage and polyadenylation specificity factor complex; mRNA cleavage factor complex; nucleoplasm; nucleus
Molecular Function:  mRNA binding; protein binding
Biological Process:  messenger ribonucleoprotein complex assembly; mRNA 3'-end processing; mRNA alternative polyadenylation; pre-mRNA cleavage required for polyadenylation; protein heterotetramerization; protein tetramerization
Reference #:  Q8N684 (UniProtKB)
Alt. Names/Synonyms: CFIm59; cleavage and polyadenylation specific factor 7; cleavage and polyadenylation specific factor 7, 59kDa; Cleavage and polyadenylation specificity factor 59 kDa subunit; Cleavage and polyadenylation specificity factor subunit 7; Cleavage factor Im complex 59 kDa subunit; CPSF 59 kDa subunit; CPSF7; FLJ12529; FLJ39024; MGC9315; pre mRNA cleavage factor I, 59 kDa subunit; pre-mRNA cleavage factor I, 59 kDa subunit; Pre-mRNA cleavage factor Im 59 kDa subunit
Gene Symbols: CPSF7
Molecular weight: 52,050 Da
Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein