THEMIS Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. Belongs to the themis family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Chromosomal Location of human Ortholog: 6q22.33
Cellular Component:  cell-cell junction; COP9 signalosome; cytoplasm; nucleus
Molecular Function:  protein binding
Biological Process:  adaptive immune response; negative T cell selection; positive T cell selection; T cell receptor signaling pathway
Reference #:  Q8N1K5 (UniProtKB)
Alt. Names/Synonyms: bA325O24.3; bA325O24.4; C6orf190; C6orf207; FLJ40584; GASP; GRB2-associated protein; MGC163388; Protein THEMIS; signaling phosphoprotein specific for T cells; SPOT; THEMIS; THMS1; thymocyte selection associated; thymocyte selection pathway associated; Thymocyte-expressed molecule involved in selection; TSEPA
Gene Symbols: THEMIS
Molecular weight: 73,452 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein