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SKA3
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. Belongs to the SKA3 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation |
| Chromosomal Location of human Ortholog: 13q12.11 |
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Cellular Component:
centrosome; cytosol; kinetochore; mitotic spindle; outer kinetochore; spindle microtubule
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Molecular Function:
protein binding
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Biological Process:
cell division; chromosome segregation; mitotic cell cycle; regulation of microtubule polymerization or depolymerization
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Reference #:
Q8IX90
(UniProtKB)
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Alt. Names/Synonyms: C13orf3; MGC4832; RAMA1; SKA3; spindle and kinetochore associated complex subunit 3; Spindle and kinetochore-associated protein 3
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Gene Symbols: SKA3
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Molecular weight:
46,359 Da
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Basal Isoelectric point:
4.99
Predict pI for various phosphorylation states
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