ARHGAP12 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho
Chromosomal Location of human Ortholog: 10p11.22
Cellular Component:  cytoplasm; phagocytic cup
Molecular Function:  GTPase activator activity
Biological Process:  actin filament organization; morphogenesis of an epithelial sheet; negative regulation of small GTPase mediated signal transduction; phagocytosis, engulfment; regulation of GTPase activity; signal transduction
Reference #:  Q8IWW6 (UniProtKB)
Alt. Names/Synonyms: ARHGAP12; DKFZp779N2050; FLJ10971; FLJ20737; FLJ21785; FLJ45709; RHG12; Rho GTPase activating protein 12; Rho GTPase-activating protein 12; Rho-type GTPase-activating protein 12
Gene Symbols: ARHGAP12
Molecular weight: 96,254 Da
Basal Isoelectric point: 7.29  Predict pI for various phosphorylation states
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ARHGAP12

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein