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endofin
May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Lipid-binding |
| Chromosomal Location of human Ortholog: 5q14.1 |
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Cellular Component:
cytosol; early endosome; early endosome membrane; intracellular membrane-bounded organelle
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Molecular Function:
1-phosphatidylinositol binding; metal ion binding; phosphatidylinositol-3,4,5-trisphosphate binding; protein binding
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Biological Process:
endosomal transport; protein targeting to lysosome; regulation of endocytosis; signal transduction; vesicle organization
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Reference #:
Q7Z3T8
(UniProtKB)
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Alt. Names/Synonyms: DKFZp686E13162; Endofin; Endosome-associated FYVE domain protein; endosome-associated FYVE-domain protein; KIAA0305; PPP1R69; protein phosphatase 1, regulatory subunit 69; ZFY16; ZFYVE16; Zinc finger FYVE domain-containing protein 16; zinc finger FYVE-type containing 16; zinc finger, FYVE domain containing 16
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Gene Symbols: ZFYVE16
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Molecular weight:
168,903 Da
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Basal Isoelectric point:
4.67
Predict pI for various phosphorylation states
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