KiSS-1 Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Belongs to the KISS1 family. Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component:  apical plasma membrane; cytoplasm; extracellular region; extracellular space; neuronal cell body
Molecular Function:  protein binding
Biological Process:  cytoskeleton organization; G protein-coupled receptor signaling pathway; generation of ovulation cycle rhythm; negative regulation of cell proliferation; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of growth hormone secretion; positive regulation of luteinizing hormone secretion; positive regulation of MAPK cascade; positive regulation of synaptic transmission
Disease: Hypogonadotropic Hypogonadism 13 With Or Without Anosmia
Reference #:  Q15726 (UniProtKB)
Alt. Names/Synonyms: KiSS-1; KiSS-1 metastasis-suppressor; KISS1; kisspeptin; Kisspeptin-1; Kisspeptin-10; Kisspeptin-13; Kisspeptin-14; Kisspeptin-54; malignant melanoma metastasis-suppressor; Metastasis-suppressor KiSS-1; Metastin; MGC39258
Gene Symbols: KISS1
Molecular weight: 14,705 Da
Basal Isoelectric point: 10.17  Predict pI for various phosphorylation states
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KiSS-1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene