ARHGEF6
Acts as a RAC1 guanine nucleotide exchange factor (GEF). Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis |
Chromosomal Location of human Ortholog: Xq26.3 |
Cellular Component:
cell-cell junction; cytoplasm; cytosol; lamellipodium
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Molecular Function:
GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding
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Biological Process:
apoptotic process; JNK cascade; lamellipodium assembly
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Disease: Mental Retardation, X-linked 46
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Reference #:
Q15052
(UniProtKB)
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Alt. Names/Synonyms: Alpha-Pix; alphaPIX; ARHG6; ARHGEF6; COOL-2; COOL2; KIAA0006; mental retardation, X-linked 46; MRX46; PAK-interacting exchange factor alpha; PAK-interacting exchange factor, alpha; PIXA; Rac/Cdc42 guanine exchange factor (GEF) 6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Rac/Cdc42 guanine nucleotide exchange factor 6; Rho guanine nucleotide exchange factor 6
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Gene Symbols: ARHGEF6
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Molecular weight:
87,499 Da
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Basal Isoelectric point:
5.79
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Microtubule Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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