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NOLC1
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. Belongs to the NOLC1 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nucleolus; RNA-binding; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 10q24.32 |
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Cellular Component:
Cajal body; cytoplasm; fibrillar center; nucleolus; nucleoplasm
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Molecular Function:
ATP binding; GTP binding; molecular function inhibitor activity; protein binding; protein heterodimerization activity; protein-macromolecule adaptor activity
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Biological Process:
mitotic cell cycle; neural crest cell development; neural crest formation; nucleolus organization; regulation of translation; rRNA processing
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Reference #:
Q14978
(UniProtKB)
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Alt. Names/Synonyms: 140 kDa nucleolar phosphoprotein; HCV NS5A trans-regulated protein 13; HCV NS5A-transactivated protein 13; Hepatitis C virus NS5A-transactivated protein 13; KIAA0035; NOLC1; NOPP130; Nopp140; NS5ATP13; Nucleolar 130 kDa protein; Nucleolar and coiled-body phosphoprotein 1; nucleolar and coiled-body phosphprotein 1; Nucleolar phosphoprotein p130; nucleolar protein p130; P130; Srp40
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Gene Symbols: NOLC1
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Molecular weight:
73,603 Da
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Basal Isoelectric point:
9.46
Predict pI for various phosphorylation states
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