dynactin 2 Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. Belongs to the dynactin subunit 2 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component:  centrosome; cytosol; dynactin complex; dynein complex; growth cone; kinetochore; membrane; microtubule; vesicle
Molecular Function:  identical protein binding; motor activity; protein binding; protein kinase binding; spectrin binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; ciliary basal body-plasma membrane docking; ER to Golgi vesicle-mediated transport; G2/M transition of mitotic cell cycle; melanosome transport; mitotic cell cycle; protein localization to centrosome; regulation of G2/M transition of mitotic cell cycle
Reference #:  Q13561 (UniProtKB)
Alt. Names/Synonyms: 50 kD dynein-associated polypeptide; 50 kDa dynein-associated polypeptide; DCTN-50; DCTN2; DCTN50; dynactin 2 (p50); dynactin complex 50 kD subunit; Dynactin complex 50 kDa subunit; Dynactin subunit 2; DYNAMITIN; p50 dynamitin; RBP50
Gene Symbols: DCTN2
Molecular weight: 44,231 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
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dynactin 2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene