RPT2 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Belongs to the AAA ATPase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Protease; Proteasome complex

Chromosomal Location of human Ortholog: 14q32.11

Cellular Component: cytosol; nucleoplasm; proteasome accessory complex; proteasome complex; proteasome regulatory particle, base subcomplex

Molecular Function: ATP binding; ATP hydrolysis activity; proteasome-activating activity; protein binding

Biological Process: negative regulation of neuron death; positive regulation of proteasomal protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process

Disease: Neurodevelopmental Disorder With Poor Growth, Spastic Tetraplegia, And Hearing Loss

Reference #: P62191 (UniProtKB)

Alt. Names/Synonyms: 26S protease regulatory subunit 4; 26S proteasome AAA-ATPase subunit RPT2; 26S proteasome regulatory subunit 4; MGC24583; MGC8541; P26s4; p56; proteasome (prosome, macropain) 26S subunit, ATPase, 1; proteasome 26S ATPase subunit 1; Proteasome 26S subunit ATPase 1; proteasome 26S subunit, ATPase 1; proteasome 26S subunit, ATPase, 1; PRS4; PSMC1; RPT2; S4

Gene Symbols: PSMC1

Molecular weight: 49,185 Da

Basal Isoelectric point: 5.87 Predict pI for various phosphorylation states

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RPT2

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