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Afadin iso3
Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Motility/polarity/chemotaxis; Oncoprotein |
| Chromosomal Location of human Ortholog: 6q27 |
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Cellular Component:
adherens junction; cell junction; cell-cell contact zone; cell-cell junction; cytosol; nuclear speck; nucleoplasm; plasma membrane; pore complex; tight junction
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Molecular Function:
actin filament binding; cell adhesion molecule binding; protein binding; small GTPase binding
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Biological Process:
bicellular tight junction assembly; cell adhesion; cell-cell adhesion mediated by cadherin; cell-cell signaling; establishment of endothelial intestinal barrier; establishment of protein localization to plasma membrane; negative regulation of cell migration; pore complex assembly; positive regulation of cell-cell adhesion; positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of gene expression; regulation of protein localization; signal transduction
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Reference #:
P55196-3
(UniProtKB)
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Alt. Names/Synonyms: AF-6; AF6; AFAD; Afadin; Afadin adherens junction formation factor; Afadin iso3; afadin, adherens junction formation factor; AFDN; ALL1-fused gene from chromosome 6 protein; FLJ34371; l-afadin; MLL-AF6; MLLT4; myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia, translocated to, 4; Protein AF-6; RP3-431P23.3; translocated to, 4
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Gene Symbols: AFDN
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Molecular weight:
197,653 Da
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Basal Isoelectric point:
6.12
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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