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SMAD2
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Belongs to the dwarfin/SMAD family. Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of Human Ortholog: 18q12.3 |
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Cellular Component:
activin responsive factor complex; cytoplasm; heteromeric SMAD protein complex; nuclear chromatin; nucleus; protein-containing complex; SMAD protein complex; transcription factor complex
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Molecular Function:
activating transcription factor binding; chromatin binding; co-SMAD binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; double-stranded DNA binding; I-SMAD binding; metal ion binding; phosphatase binding; primary miRNA binding; protein binding; protein heterodimerization activity; protein homodimerization activity; R-SMAD binding; RNA polymerase II proximal promoter sequence-specific DNA binding; SMAD binding; tau protein binding; transcription factor binding; transforming growth factor beta receptor binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; type I transforming growth factor beta receptor binding; ubiquitin protein ligase binding
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Biological Process:
activin receptor signaling pathway; adrenal gland development; anterior/posterior pattern specification; cell fate commitment; common-partner SMAD protein phosphorylation; developmental growth; embryonic cranial skeleton morphogenesis; embryonic foregut morphogenesis; embryonic pattern specification; endoderm development; endoderm formation; gastrulation; heart development; in utero embryonic development; insulin secretion; intracellular signal transduction; lung development; mesoderm formation; negative regulation of cell proliferation; negative regulation of gene expression; negative regulation of transcription, DNA-templated; nodal signaling pathway; organ growth; pancreas development; paraxial mesoderm morphogenesis; pattern specification process; pericardium development; positive regulation of BMP signaling pathway; positive regulation of epithelial to mesenchymal transition; positive regulation of gene expression; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; post-embryonic development; protein phosphorylation; regulation of binding; regulation of transcription, DNA-templated; regulation of transforming growth factor beta receptor signaling pathway; response to cholesterol; response to glucose; secondary palate development; signal transduction involved in regulation of gene expression; SMAD protein complex assembly; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway; ureteric bud development; wound healing; zygotic specification of dorsal/ventral axis
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Reference #:
O70436
(UniProtKB)
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Alt. Names/Synonyms: MAD (mothers against decapentaplegic Drosophila) homolog 2; MAD homolog 2; Mad-related protein 2; Madh2; MGC156656; Mothers against decapentaplegic homolog 2; Mothers against DPP homolog 2; SMAD 2; SMAD family member 2; Smad2
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Gene Symbols: Smad2
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Molecular weight:
52,239 Da
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Basal Isoelectric point:
6.13
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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ESC Pluripotency and Differentiation
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TGF-ß Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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