RBMX RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. Expressed strongly in oral keratinocytes, but only weakly detected in oral squamous cell carcinomas (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA splicing; RNA-binding; Spliceosome; Tumor suppressor
Chromosomal Location of human Ortholog: Xq26.3
Cellular Component:  catalytic step 2 spliceosome; extracellular exosome; nuclear euchromatin; nucleoplasm; nucleus; ribonucleoprotein complex; supraspliceosomal complex
Molecular Function:  chromatin binding; identical protein binding; mRNA binding; protein binding; protein domain specific binding; RNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  cellular response to interleukin-1; membrane protein ectodomain proteolysis; mRNA splicing, via spliceosome; negative regulation of mRNA splicing, via spliceosome; positive regulation of mRNA splicing, via spliceosome; positive regulation of transcription by RNA polymerase II; protein complex oligomerization; protein homooligomerization; regulation of alternative mRNA splicing, via spliceosome; RNA metabolic process; transcription by RNA polymerase II
Disease: Mental Retardation, X-linked, Syndromic 11
Reference #:  P38159 (UniProtKB)
Alt. Names/Synonyms: Glycoprotein p43; Heterogeneous nuclear ribonucleoprotein G; Heterogeneous nuclear ribonucleoprotein G, N-terminally processed; hnRNP G; hnRNP-G; HNRNPG; HNRPG; MRXS11; RBMX; RBMXP1; RBMXRT; RNA binding motif protein X-linked; RNA binding motif protein, X chromosome; RNA binding motif protein, X-linked; RNA-binding motif protein, X chromosome; RNA-binding motif protein, X chromosome, N-terminally processed; RNMX
Gene Symbols: RBMX
Molecular weight: 42,332 Da
Basal Isoelectric point: 10.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene