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PTPRB
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine |
| Chromosomal Location of human Ortholog: 12q15 |
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Cellular Component:
plasma membrane; receptor complex; specific granule membrane; tertiary granule membrane
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Molecular Function:
cadherin binding; protein binding; transmembrane receptor protein tyrosine phosphatase activity
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Biological Process:
angiogenesis; dephosphorylation; glial cell migration; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; phosphate-containing compound metabolic process; protein dephosphorylation
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Reference #:
P23467
(UniProtKB)
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Alt. Names/Synonyms: DKFZp686E2262; DKFZp686H15164; FLJ44133; HPTP-BETA; HPTPB; MGC142023; MGC59935; protein tyrosine phosphatase receptor type B; protein tyrosine phosphatase, receptor type, B; protein tyrosine phosphatase, receptor type, beta polypeptide; Protein-tyrosine phosphatase beta; PTPB; PTPRB; R-PTP-beta; Receptor-type tyrosine-protein phosphatase beta; Vascular endothelial protein tyrosine phosphatase; VE-PTP; VEPTP
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Gene Symbols: PTPRB
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Molecular weight:
224,301 Da
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Basal Isoelectric point:
7.44
Predict pI for various phosphorylation states
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