PTPRB Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 12q15
Cellular Component:  integral component of plasma membrane; plasma membrane; receptor complex; specific granule membrane; tertiary granule membrane
Molecular Function:  protein binding; transmembrane receptor protein tyrosine phosphatase activity
Biological Process:  angiogenesis; dephosphorylation; neutrophil degranulation; peptidyl-tyrosine dephosphorylation; phosphate-containing compound metabolic process; protein dephosphorylation
Reference #:  P23467 (UniProtKB)
Alt. Names/Synonyms: DKFZp686E2262; DKFZp686H15164; FLJ44133; HPTP-BETA; HPTPB; MGC142023; MGC59935; protein tyrosine phosphatase, receptor type, B; protein tyrosine phosphatase, receptor type, beta polypeptide; Protein-tyrosine phosphatase beta; PTPB; PTPRB; R-PTP-beta; Receptor-type tyrosine-protein phosphatase beta; Vascular endothelial protein tyrosine phosphatase; VE-PTP; VEPTP
Gene Symbols: PTPRB
Molecular weight: 224,301 Da
Basal Isoelectric point: 7.44  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein