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FOP
Required for anchoring microtubules to the centrosomes. Required for ciliation. Belongs to the FGFR1OP family. Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of human Ortholog: 6q27 |
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Cellular Component:
cell projection; centriole; centrosome; cytosol; nucleus; perinuclear region of cytoplasm
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Molecular Function:
protein binding; protein homodimerization activity; protein kinase binding; protein tyrosine kinase inhibitor activity
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Biological Process:
cell projection organization; microtubule anchoring; negative regulation of protein kinase activity; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation
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Reference #:
O95684
(UniProtKB)
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Alt. Names/Synonyms: Centrosomal protein 43; CEP43; FGFR1 oncogene partner; FGFR1OP; fibroblast growth factor receptor 1 oncogene partner; FOP; FR1OP
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Gene Symbols: CEP43
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Molecular weight:
43,065 Da
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Basal Isoelectric point:
4.67
Predict pI for various phosphorylation states
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