latrophilin 1 Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 19p13.12
Cellular Component:  axon; cell junction; growth cone; integral component of membrane; neuron projection; plasma membrane; presynaptic membrane; synapse
Molecular Function:  carbohydrate binding; cell adhesion molecule binding; latrotoxin receptor activity; protein binding
Biological Process:  calcium-mediated signaling using intracellular calcium source; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of synapse assembly; positive regulation of synapse maturation
Reference #:  O94910 (UniProtKB)
Alt. Names/Synonyms: Adhesion G protein-coupled receptor L1; Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; CIRL1; CL1; KIAA0821; latrophilin 1; Latrophilin-1; LEC2; Lectomedin-2; LPHN1
Gene Symbols: ADGRL1
Molecular weight: 162,717 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
Select Structure to View Below

latrophilin 1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein