RBM14 Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Expressed in all tissues tested, including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Nucleolus; RNA-binding
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component:  cytoplasm; mediator complex; nuclear speck; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex; transcription factor complex
Molecular Function:  nuclear receptor transcription coactivator activity; protein binding; protein binding, bridging; RNA binding; transcription coregulator activity
Biological Process:  activation of innate immune response; centriole assembly; DNA recombination; DNA repair; DNA replication; glucocorticoid receptor signaling pathway; histone deacetylation; innate immune response; intracellular estrogen receptor signaling pathway; negative regulation of centriole replication; positive regulation of transcription by RNA polymerase II; response to hormone; SMAD protein signal transduction
Reference #:  Q96PK6 (UniProtKB)
Alt. Names/Synonyms: COAA; coactivator activator; DKFZp779J0927; MGC15912; MGC31756; Paraspeckle protein 2; PSP2; RBM14; RNA binding motif protein 14; RNA-binding motif protein 14; RNA-binding protein 14; RRM-containing coactivator activator/modulator; SIP; Synaptotagmin-interacting protein; SYT interacting protein; SYT-interacting protein; SYTIP1; TMEM137; transmembrane protein 137
Gene Symbols: RBM14
Molecular weight: 69,492 Da
Basal Isoelectric point: 9.68  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein