GADS Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. Belongs to the GRB2/sem-5/DRK family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component:  cytoplasm; cytosol; endosome; nucleus
Molecular Function:  protein binding; SH3/SH2 adaptor activity
Biological Process:  cell-cell signaling; Fc-epsilon receptor signaling pathway; positive regulation of signal transduction; Ras protein signal transduction; T cell costimulation; T cell receptor signaling pathway
Reference #:  O75791 (UniProtKB)
Alt. Names/Synonyms: Adapter protein GRID; GADS; GRAP-2; GRAP2; GRB-2-like protein; GRB2-related adapter protein 2; GRB2-related adaptor protein 2; GRB2-related protein with insert domain; GRB2L; GRBLG; GRBX; Grf-40; Grf40; Grf40 adapter protein; GRID; Growth factor receptor-binding protein; growth factor receptor-bound protein 2-related adaptor protein 2; GRPL; Hematopoietic cell-associated adapter protein GrpL; hematopoietic cell-associated adaptor protein GRPL; Mona; P38; Protein GADS; SH3-SH2-SH3 adapter Mona; SH3-SH2-SH3 adaptor molecule
Gene Symbols: GRAP2
Molecular weight: 37,909 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB