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OTUD4
Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.19.12; Hydrolase |
| Chromosomal Location of human Ortholog: 4q31.21 |
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Cellular Component:
cytoplasm; cytosol; nucleus
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Molecular Function:
cysteine-type deubiquitinase activity; K63-linked deubiquitinase activity; molecular adaptor activity; protein binding
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Biological Process:
innate immune response; negative regulation of interleukin-1-mediated signaling pathway; negative regulation of toll-like receptor signaling pathway; positive regulation of DNA demethylation; protein deubiquitination; protein K11-linked deubiquitination; protein K48-linked deubiquitination; protein K63-linked deubiquitination; regulation of protein K48-linked deubiquitination
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Reference #:
Q01804
(UniProtKB)
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Alt. Names/Synonyms: DKFZp434I0721; DUBA6; HIN-1; HIN1; HIV-1 induced protein HIN-1; HIV-1-induced protein HIN-1; HSHIN1; KIAA1046; OTU deubiquitinase 4; OTU domain containing 4; OTU domain-containing protein 4; OTUD4; OTUD4 protein
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Gene Symbols: OTUD4
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Molecular weight:
124,044 Da
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Basal Isoelectric point:
6.25
Predict pI for various phosphorylation states
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