Afadin Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 6q27
Cellular Component:  cell junction; cell-cell contact zone; cell-cell junction; cytosol; nuclear speck; nucleoplasm; plasma membrane; tight junction
Molecular Function:  actin filament binding; protein binding; protein C-terminus binding; Ras GTPase binding
Biological Process:  adherens junction organization; bicellular tight junction assembly; cell adhesion; cell-cell adhesion mediated by cadherin; cell-cell signaling; establishment of endothelial intestinal barrier; establishment of protein localization to plasma membrane; negative regulation of cell migration; positive regulation of cell-cell adhesion; positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of gene expression; positive regulation of GTPase activity; signal transduction
Reference #:  P55196 (UniProtKB)
Alt. Names/Synonyms: AF-6; AF6; AFAD; Afadin; AFDN; ALL1-fused gene from chromosome 6 protein; FLJ34371; MLLT4; myeloid/lymphoid or mixed-lineage leukemia, translocated to, 4; Protein AF-6; RP3-431P23.3; translocated to, 4
Gene Symbols: AFDN
Molecular weight: 206,804 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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