FHOD1 Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. Belongs to the formin homology family. Ubiquitous. Highly expressed in spleen. Note: This description may include information from UniProtKB.
Protein type: Actin-binding
Chromosomal Location of mouse Ortholog: 8|8 D3
Cellular Component:  cell; cell projection; cytoplasm; cytoskeleton; intercalated disc
Molecular Function:  actin binding
Biological Process:  establishment of centrosome localization; nuclear migration; regulation of stress fiber assembly
Reference #:  Q6P9Q4 (UniProtKB)
Alt. Names/Synonyms: BC017144; FH1/FH2 domain-containing protein 1; Fhod1; FHOS; Fhos1; Formin homolog overexpressed in spleen 1; formin homology 2 domain containing 1; Formin homology 2 domain-containing protein 1
Gene Symbols: Fhod1
Molecular weight: 129,600 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene