C3 C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2. Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  azurophil granule lumen; cell surface; endoplasmic reticulum lumen; extracellular region; extracellular space; plasma membrane; protein-containing complex; secretory granule lumen
Molecular Function:  C5L2 anaphylatoxin chemotactic receptor binding; endopeptidase inhibitor activity; protein binding; signaling receptor binding
Biological Process:  amyloid-beta clearance; cell surface receptor signaling pathway involved in cell-cell signaling; cellular protein metabolic process; complement activation; complement activation, alternative pathway; complement activation, classical pathway; complement-dependent cytotoxicity; complement-mediated synapse pruning; fatty acid metabolic process; G protein-coupled receptor signaling pathway; immune response; inflammatory response; negative regulation of endopeptidase activity; neuron remodeling; neutrophil degranulation; positive regulation of activation of membrane attack complex; positive regulation of angiogenesis; positive regulation of apoptotic cell clearance; positive regulation of G protein-coupled receptor signaling pathway; positive regulation of glucose transmembrane transport; positive regulation of lipid storage; positive regulation of phagocytosis, engulfment; positive regulation of protein phosphorylation; positive regulation of receptor-mediated endocytosis; positive regulation of type IIa hypersensitivity; positive regulation of vascular endothelial growth factor production; post-translational protein modification; regulation of complement activation; regulation of immune response; regulation of triglyceride biosynthetic process; response to bacterium; signal transduction; vertebrate eye-specific patterning
Disease: Complement Component 3 Deficiency, Autosomal Recessive; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 5; Macular Degeneration, Age-related, 9
Reference #:  P01024 (UniProtKB)
Alt. Names/Synonyms: Acylation stimulating protein; acylation-stimulating protein cleavage product; AHUS5; ARMD9; ASP; C3; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3-beta-c; C3a; C3a anaphylatoxin; C3adesArg; C3b; C3bc; CO3; Complement C3; Complement C3 alpha chain; Complement C3 beta chain; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3c alpha' chain fragment 2; Complement C3d fragment; Complement C3dg fragment; Complement C3f fragment; Complement C3g fragment; complement component 3; complement component C3; complement component C3a; complement component C3b; CPAMD1; epididymis secretory sperm binding protein Li 62p; HEL-S-62p; prepro-C3
Gene Symbols: C3
Molecular weight: 187,148 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB