CGA Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. Belongs to the glycoprotein hormones subunit alpha family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of mouse Ortholog: 4 A5|4 16.86 cM
Cellular Component:  extracellular region; extracellular space; follicle-stimulating hormone complex; pituitary gonadotropin complex
Molecular Function:  follicle-stimulating hormone activity; hormone activity
Biological Process:  cellular response to hormone stimulus; developmental growth; follicle-stimulating hormone secretion; G protein-coupled receptor signaling pathway; gonad development; luteinizing hormone secretion; negative regulation of organ growth; organ growth; positive regulation of steroid biosynthetic process; regulation of signaling receptor activity; thyroid gland development; thyroid hormone generation
Reference #:  P01216 (UniProtKB)
Alt. Names/Synonyms: aGSU; alp; alph; alpha-GSU; alphaGSU; alphaSU; Anterior pituitary glycoprotein hormones common subunit alpha; CG-alpha; Cga; Follicle-stimulating hormone alpha chain; Follitropin alpha chain; FSH-alpha; FSHA; GLHA; Glycoprotein hormones alpha chain; glycoprotein hormones, alpha subunit; GPH; GPHA1; GPHalpha; HCG; LHA; LSH-alpha; Luteinizing hormone alpha chain; Lutropin alpha chain; MGC107283; OTTMUSP00000006878; OTTMUSP00000006880; Thyroid-stimulating hormone alpha chain; Thyrotropin alpha chain; TSH-alpha; Tsha
Gene Symbols: Cga
Molecular weight: 13,565 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein