SMAD2 ubiquitously expressed transcription factor phosphorylated and activated by TGF-beta receptor-type kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where the transcription of target genes is stimulated. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 18 E3|18 51.42 cM
Cellular Component:  activin responsive factor complex; cytoplasm; heteromeric SMAD protein complex; nuclear chromatin; nucleus; protein-containing complex; SMAD protein complex; transcription factor complex
Molecular Function:  activating transcription factor binding; chromatin binding; co-SMAD binding; disordered domain specific binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; double-stranded DNA binding; I-SMAD binding; metal ion binding; phosphatase binding; primary miRNA binding; protein binding; protein heterodimerization activity; protein homodimerization activity; R-SMAD binding; RNA polymerase II proximal promoter sequence-specific DNA binding; SMAD binding; tau protein binding; transcription factor binding; transforming growth factor beta receptor binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; type I transforming growth factor beta receptor binding; ubiquitin protein ligase binding
Biological Process:  activin receptor signaling pathway; adrenal gland development; anterior/posterior pattern specification; cell fate commitment; common-partner SMAD protein phosphorylation; developmental growth; embryonic cranial skeleton morphogenesis; embryonic foregut morphogenesis; embryonic pattern specification; endoderm development; endoderm formation; gastrulation; heart development; in utero embryonic development; insulin secretion; intracellular signal transduction; lung development; mesoderm formation; negative regulation of cell proliferation; negative regulation of gene expression; negative regulation of transcription, DNA-templated; nodal signaling pathway; organ growth; pancreas development; paraxial mesoderm morphogenesis; pattern specification process; pericardium development; positive regulation of BMP signaling pathway; positive regulation of epithelial to mesenchymal transition; positive regulation of gene expression; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; post-embryonic development; protein phosphorylation; regulation of binding; regulation of transcription, DNA-templated; regulation of transforming growth factor beta receptor signaling pathway; response to cholesterol; response to glucose; secondary palate development; signal transduction involved in regulation of gene expression; SMAD protein complex assembly; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway; ureteric bud development; zygotic specification of dorsal/ventral axis
Reference #:  Q62432 (UniProtKB)
Alt. Names/Synonyms: MAD homolog 2; MAD homolog 2 (Drosophila); Mad-related protein 2; Madh2; Madr2; mMad2; Mothers against decapentaplegic homolog 2; Mothers against DPP homolog 2; SMAD 2; SMAD family member 2; Smad2
Gene Symbols: Smad2
Molecular weight: 52,266 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene