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SMAD2
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Belongs to the dwarfin/SMAD family. Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 18q21.1 |
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Cellular Component:
activin responsive factor complex; chromatin; cytoplasm; cytosol; heteromeric SMAD protein complex; homomeric SMAD protein complex; nucleoplasm; nucleus; protein-containing complex; SMAD protein complex; transcription regulator complex
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Molecular Function:
chromatin binding; cis-regulatory region sequence-specific DNA binding; co-SMAD binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; double-stranded DNA binding; I-SMAD binding; identical protein binding; metal ion binding; phosphatase binding; protein binding; R-SMAD binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; SMAD binding; tau protein binding; transforming growth factor beta receptor binding; type I transforming growth factor beta receptor binding; ubiquitin protein ligase binding
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Biological Process:
activin receptor signaling pathway; adrenal gland development; anatomical structure morphogenesis; anterior/posterior pattern specification; aortic valve morphogenesis; cell differentiation; cell fate commitment; common-partner SMAD protein phosphorylation; DNA-templated transcription; embryonic cranial skeleton morphogenesis; embryonic foregut morphogenesis; endocardial cushion morphogenesis; endoderm formation; gastrulation; in utero embryonic development; insulin secretion; intracellular signal transduction; lung development; mesoderm formation; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; nodal signaling pathway; organ growth; pancreas development; paraxial mesoderm morphogenesis; pericardium development; positive regulation of BMP signaling pathway; positive regulation of DNA-templated transcription; positive regulation of epithelial to mesenchymal transition; positive regulation of gene expression; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; positive regulation of transcription by RNA polymerase II; post-embryonic development; primary miRNA processing; pulmonary valve morphogenesis; regulation of binding; regulation of transforming growth factor beta receptor signaling pathway; response to cholesterol; response to glucose; secondary palate development; signal transduction involved in regulation of gene expression; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway; ureteric bud development; zygotic specification of dorsal/ventral axis
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Disease: Arthrogryposis, Distal, Type 9; Congenital Heart Defects, Multiple Types, 8, With Or Without Heterotaxy; Desbuquois Dysplasia 2; Loeys-dietz Syndrome 6; Marfan Syndrome; Shprintzen-goldberg Craniosynostosis Syndrome
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Reference #:
Q15796
(UniProtKB)
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Alt. Names/Synonyms: hMAD-2; hSMAD2; JV18; JV18-1; MAD homolog 2; Mad protein homolog; MAD, mothers against decapentaplegic homolog 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; mother against DPP homolog 2; Mothers against decapentaplegic homolog 2; Mothers against DPP homolog 2; Sma- and Mad-related protein 2; SMAD 2; SMAD family member 2; SMAD, mothers against DPP homolog 2; SMAD2
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Gene Symbols: SMAD2
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Molecular weight:
52,306 Da
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Basal Isoelectric point:
6.13
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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ESC Pluripotency and Differentiation
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TGF-ß Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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