SMAD2 Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Belongs to the dwarfin/SMAD family. Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 18q21.1
Cellular Component:  activin responsive factor complex; cytoplasm; cytosol; heteromeric SMAD protein complex; nuclear chromatin; nucleoplasm; nucleus; protein-containing complex; SMAD protein complex; transcription factor complex
Molecular Function:  activating transcription factor binding; chromatin binding; co-SMAD binding; disordered domain specific binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; enhancer binding; I-SMAD binding; metal ion binding; phosphatase binding; primary miRNA binding; protein binding; protein heterodimerization activity; protein homodimerization activity; R-SMAD binding; RNA polymerase II proximal promoter sequence-specific DNA binding; SMAD binding; tau protein binding; transcription factor binding; transforming growth factor beta receptor binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; type I transforming growth factor beta receptor binding; ubiquitin protein ligase binding
Biological Process:  activin receptor signaling pathway; adrenal gland development; anterior/posterior pattern specification; cell fate commitment; common-partner SMAD protein phosphorylation; embryonic cranial skeleton morphogenesis; embryonic foregut morphogenesis; endoderm formation; gastrulation; in utero embryonic development; insulin secretion; intracellular signal transduction; lung development; mesoderm formation; negative regulation of cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of transforming growth factor beta receptor signaling pathway; nodal signaling pathway; organ growth; pancreas development; paraxial mesoderm morphogenesis; pericardium development; positive regulation of BMP signaling pathway; positive regulation of epithelial to mesenchymal transition; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; post-embryonic development; primary miRNA processing; protein deubiquitination; regulation of binding; regulation of transforming growth factor beta receptor signaling pathway; response to cholesterol; response to glucose; secondary palate development; signal transduction involved in regulation of gene expression; SMAD protein complex assembly; SMAD protein signal transduction; somatic stem cell population maintenance; transforming growth factor beta receptor signaling pathway; ureteric bud development; wound healing; zygotic specification of dorsal/ventral axis
Reference #:  Q15796 (UniProtKB)
Alt. Names/Synonyms: hMAD-2; hSMAD2; JV18; JV18-1; MAD homolog 2; Mad protein homolog; MAD, mothers against decapentaplegic homolog 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; mother against DPP homolog 2; Mothers against decapentaplegic homolog 2; Mothers against DPP homolog 2; Sma- and Mad-related protein 2; SMAD 2; SMAD family member 2; SMAD, mothers against DPP homolog 2; SMAD2
Gene Symbols: SMAD2
Molecular weight: 52,306 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein