MGP Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. Belongs to the osteocalcin/matrix Gla protein family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6|6 G1
Cellular Component:  collagen-containing extracellular matrix; endoplasmic reticulum; extracellular matrix; extracellular region; extracellular space; protein-containing complex
Molecular Function:  calcium ion binding; calcium-dependent protein binding
Biological Process:  branching morphogenesis of an epithelial tube; cartilage development; cell differentiation; lung development; multicellular organism development; ossification; protein-containing complex assembly; regulation of bone mineralization
Reference #:  P19788 (UniProtKB)
Alt. Names/Synonyms: matrix gamma-carboxyglutamate (gla) protein; Matrix Gla protein; Mglap; MGP
Gene Symbols: Mgp
Molecular weight: 12,359 Da
Basal Isoelectric point: 9.6  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene