H1C
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding |
Chromosomal Location of mouse Ortholog: 13|13 A3.1 |
Cellular Component:
chromosome; euchromatin; nucleosome; nucleus
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Molecular Function:
chromatin DNA binding; DNA binding; double-stranded DNA binding; nucleosomal DNA binding; protein binding; structural constituent of chromatin
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Biological Process:
chromatin organization; chromosome condensation; histone H3-K27 trimethylation; histone H3-K4 trimethylation; negative regulation of DNA recombination; negative regulation of transcription by RNA polymerase II; nucleosome assembly; regulation of transcription by RNA polymerase II
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Reference #:
P15864
(UniProtKB)
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Alt. Names/Synonyms: 0610008C09Rik; H1 histone family, member 2; H1 VAR.1; H1-2; H1.2; H1.2 linker histone, cluster member; H12; H1c; H1f2; H1v; H1var1; His1a; Hist1h; Hist1h1c; histone 1, H1c; histone cluster 1, H1c; histone H1; Histone H1.2; MGC107646; OTTMUSP00000000652
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Gene Symbols: H1f2
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Molecular weight:
21,267 Da
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Basal Isoelectric point:
11
Predict pI for various phosphorylation states
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