sialophorin Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR. Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1. CD43 cytoplasmic tail: Protects cells from apoptotic signals, promoting cell survival. Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7 F3|7 69.35 cM
Cellular Component:  basement membrane; cell projection; cell surface; cleavage furrow; external side of plasma membrane; extracellular space; integral component of membrane; integral component of plasma membrane; membrane; microvillus; nucleus; uropod
Molecular Function:  heat shock protein binding; Hsp70 protein binding; protein binding; protein domain specific binding; transmembrane signaling receptor activity
Biological Process:  apoptotic signaling pathway; cell surface receptor signaling pathway; defense response to bacterium; interferon-gamma production; leukocyte tethering or rolling; negative regulation of cell adhesion; negative regulation of T cell activation; negative regulation of T cell proliferation; negative regulation of type IV hypersensitivity; negative thymic T cell selection; positive regulation of protein phosphorylation; positive regulation of T cell migration; positive regulation of T cell proliferation; positive regulation of tumor necrosis factor biosynthetic process; regulation of defense response to virus; regulation of gene expression; regulation of immune response; regulation of T cell activation; regulation of T cell migration; response to protozoan; T cell costimulation; T cell receptor signaling pathway; T-helper 1 cell lineage commitment; thymocyte aggregation
Reference #:  P15702 (UniProtKB)
Alt. Names/Synonyms: 3E8 antigen; A630014B01Rik; B-cell differentiation antigen LP-3; Cd43; Galgp; LEUK; Leukocyte sialoglycoprotein; Leukosialin; Ly-48; Ly48; Lymphocyte antigen 48; Sialophorin; Spn
Gene Symbols: Spn
Molecular weight: 40,038 Da
Basal Isoelectric point: 4.9  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene