AMPD2 AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Highly expressed in cerebellum. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.5.4.6; Hydrolase; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component:  cytosol
Molecular Function:  AMP deaminase activity; metal ion binding; protein binding
Biological Process:  cyclic purine nucleotide metabolic process; energy homeostasis; IMP biosynthetic process; IMP salvage; purine-containing compound salvage
Disease: Pontocerebellar Hypoplasia, Type 9; Spastic Paraplegia 63, Autosomal Recessive
Reference #:  Q01433 (UniProtKB)
Alt. Names/Synonyms: adenosine monophosphate deaminase 2; adenosine monophosphate deaminase 2 (isoform L); AMP deaminase 2; AMP deaminase isoform L; AMPD; AMPD2
Gene Symbols: AMPD2
Molecular weight: 100,688 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
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AMPD2

Protein Structure Not Found.


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