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AMPD2
AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Highly expressed in cerebellum. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.5.4.6; Hydrolase; Nucleotide Metabolism - purine |
| Chromosomal Location of human Ortholog: 1p13.3 |
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Cellular Component:
cytosol
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Molecular Function:
AMP deaminase activity; metal ion binding; protein binding
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Biological Process:
AMP metabolic process; cyclic purine nucleotide metabolic process; energy homeostasis; IMP biosynthetic process; IMP salvage
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Disease: Pontocerebellar Hypoplasia, Type 9; Spastic Paraplegia 63, Autosomal Recessive
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Reference #:
Q01433
(UniProtKB)
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Alt. Names/Synonyms: adenosine monophosphate deaminase 2; adenosine monophosphate deaminase 2 (isoform L); AMP deaminase 2; AMP deaminase isoform L; AMPD; AMPD2; PCH9; SPG63
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Gene Symbols: AMPD2
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Molecular weight:
94,890 Da
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Basal Isoelectric point:
6.1
Predict pI for various phosphorylation states
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