TPM1 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Belongs to the tropomyosin family. Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 15q22.2
Cellular Component:  actin cytoskeleton; bleb; cytoskeleton; cytosol; muscle thin filament tropomyosin; ruffle membrane; sarcomere; stress fiber
Molecular Function:  actin binding; actin filament binding; cytoskeletal protein binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; structural constituent of cytoskeleton; structural constituent of muscle
Biological Process:  cardiac muscle contraction; cellular response to reactive oxygen species; cytoskeleton organization; in utero embryonic development; muscle contraction; muscle filament sliding; negative regulation of cell migration; negative regulation of vascular associated smooth muscle cell migration; negative regulation of vascular smooth muscle cell proliferation; positive regulation of ATPase activity; positive regulation of cell adhesion; positive regulation of heart rate by epinephrine; positive regulation of stress fiber assembly; regulation of cell shape; regulation of heart contraction; regulation of muscle contraction; ruffle organization; sarcomere organization; ventricular cardiac muscle tissue morphogenesis; wound healing
Disease: Cardiomyopathy, Dilated, 1y; Cardiomyopathy, Familial Hypertrophic, 3
Reference #:  P09493 (UniProtKB)
Alt. Names/Synonyms: alpha tropomyosin; Alpha-tropomyosin; C15orf13; cardiomyopathy, hypertrophic 3; CMD1Y; CMH3; epididymis secretory protein Li 265; HEL-S-265; HTM-alpha; LVNC9; sarcomeric tropomyosin kappa; TMSA; TPM1; tropomyosin 1; tropomyosin 1 (alpha); Tropomyosin alpha-1 chain; Tropomyosin-1
Gene Symbols: TPM1
Molecular weight: 32,709 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TPM1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein