TPM1 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Belongs to the tropomyosin family. Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of mouse Ortholog: 9 C|9 36.27 cM
Cellular Component:  actin cytoskeleton; actin filament; cytoplasm; cytoskeleton; muscle thin filament tropomyosin; myofibril; protein-containing complex
Molecular Function:  actin binding; actin filament binding; disordered domain specific binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein N-terminus binding; structural constituent of cytoskeleton
Biological Process:  actin filament capping; actin filament organization; cardiac muscle contraction; in utero embryonic development; muscle filament sliding; negative regulation of cell migration; positive regulation of ATPase activity; positive regulation of cell adhesion; positive regulation of heart rate by epinephrine; positive regulation of stress fiber assembly; regulation of ATPase activity; ruffle organization; ventricular cardiac muscle tissue morphogenesis; wound healing
Reference #:  P58771 (UniProtKB)
Alt. Names/Synonyms: AA986836; AI854628; alph; alpha tropomyosin; alpha-TM; Alpha-tropomyosin; OTTMUSP00000022205; TM2; Tm3; Tmpa; Tpm-; Tpm-1; Tpm1; TPM1kappa; Tpma; tropomyosin 1 kappa; tropomyosin 1, alpha; Tropomyosin alpha-1 chain; Tropomyosin-1
Gene Symbols: Tpm1
Molecular weight: 32,681 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein