IL7R Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). Belongs to the type I cytokine receptor family. Type 4 subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of mouse Ortholog: 15 A1|15 4.16 cM
Cellular Component:  external side of plasma membrane; integral component of membrane; membrane
Molecular Function:  cytokine receptor activity
Biological Process:  B cell proliferation; cell morphogenesis; homeostasis of number of cells; immunoglobulin production; lymph node development; negative regulation of T cell apoptotic process; negative regulation of T cell mediated cytotoxicity; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of STAT cascade; positive regulation of T cell differentiation in thymus; regulation of cell size; T cell differentiation
Reference #:  P16872 (UniProtKB)
Alt. Names/Synonyms: CD127; IL-; IL-7 receptor alpha chain; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; IL-7Ralpha; Il7r; IL7RA; interleukin 7 receptor; interleukin 7 receptor alpha chain; Interleukin-7 receptor subunit alpha; MGC107557
Gene Symbols: Il7r
Molecular weight: 51,605 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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IL7R

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene