ODC Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; Cell cycle regulation; EC 4.1.1.17; Lyase; Other Amino Acids Metabolism - glutathione
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component:  cytoplasm; cytosol; perinuclear region of cytoplasm
Molecular Function:  ornithine decarboxylase activity; protein binding; protein homodimerization activity
Biological Process:  kidney development; polyamine metabolic process; positive regulation of cell proliferation; putrescine biosynthetic process from ornithine; regulation of cellular amino acid metabolic process; regulation of protein catabolic process; response to virus
Disease: Colorectal Cancer
Reference #:  P11926 (UniProtKB)
Alt. Names/Synonyms: DCOR; ODC; ODC1; Ornithine decarboxylase; ornithine decarboxylase 1
Gene Symbols: ODC1
Molecular weight: 51,148 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
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ODC

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene