SELP Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Belongs to the selectin/LECAM family. Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of mouse Ortholog: 1 H2.2|1 71.42 cM
Cellular Component:  external side of plasma membrane; extracellular space; membrane; plasma membrane; platelet alpha granule membrane
Molecular Function:  calcium ion binding; calcium-dependent protein binding; carbohydrate binding; fucose binding; heparin binding; lipopolysaccharide binding; metal ion binding; oligosaccharide binding; protein binding; sialic acid binding
Biological Process:  calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; calcium-mediated signaling using intracellular calcium source; cell adhesion; cell-cell adhesion; cellular response to interleukin-6; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; inflammatory response; leukocyte cell-cell adhesion; leukocyte migration; leukocyte tethering or rolling; positive regulation of cell adhesion; positive regulation of leukocyte migration; positive regulation of leukocyte tethering or rolling; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of platelet activation; regulation of cellular extravasation; regulation of integrin activation; response to cytokine
Reference #:  Q01102 (UniProtKB)
Alt. Names/Synonyms: CD62; CD62 antigen-like family member P; CD62P; GMP-140; Granule membrane protein 140; Grmp; LECAM3; Leukocyte-endothelial cell adhesion molecule 3; LYAM3; MGC129336; MGC129337; P selectin; P-sel; P-selectin; PADGEM; Platelet activation dependent granule-external membrane protein; selectin, platelet; Selp
Gene Symbols: Selp
Molecular weight: 83,099 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein