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RAP1B
GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. Belongs to the small GTPase superfamily. Ras family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras |
| Chromosomal Location of mouse Ortholog: 10|10 D2 |
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Cellular Component:
anchoring junction; cell-cell junction; cytoplasm; cytosol; glutamatergic synapse; lipid droplet; membrane; plasma membrane
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Molecular Function:
G protein activity; GDP binding; GTP binding; GTPase activity; hydrolase activity; nucleotide binding; protein binding; protein-containing complex binding
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Biological Process:
calcium-ion regulated exocytosis; cell population proliferation; cellular response to cAMP; cellular response to organic cyclic compound; cellular response to xenobiotic stimulus; establishment of localization in cell; modification of postsynaptic structure; negative regulation of calcium ion-dependent exocytosis; negative regulation of synaptic vesicle exocytosis; positive regulation of ERK1 and ERK2 cascade; Rap protein signal transduction; signal transduction; small GTPase mediated signal transduction
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Reference #:
Q99JI6
(UniProtKB)
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Alt. Names/Synonyms: 2810443E11Rik; GTP-binding protein smg p21B; Rap1b; RAS related protein 1b; Ras-related protein Rap-1b
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Gene Symbols: Rap1b
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Molecular weight:
20,825 Da
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Basal Isoelectric point:
5.65
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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B Cell Receptor Signaling
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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