RAP1B GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. Belongs to the small GTPase superfamily. Ras family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras
Chromosomal Location of human Ortholog: 12q15
Cellular Component:  azurophil granule membrane; cell-cell junction; cytosol; glutamatergic synapse; lipid droplet; membrane; membrane raft; plasma membrane
Molecular Function:  G protein activity; GDP binding; GTP binding; GTPase activity; protein binding; protein-containing complex binding
Biological Process:  calcium-ion regulated exocytosis; cell population proliferation; cellular response to cAMP; establishment of endothelial barrier; establishment of localization in cell; microvillus assembly; modification of postsynaptic structure; negative regulation of calcium ion-dependent exocytosis; negative regulation of synaptic vesicle exocytosis; positive regulation of ERK1 and ERK2 cascade; positive regulation of integrin activation; Rap protein signal transduction; regulation of cell junction assembly; regulation of establishment of cell polarity
Reference #:  P61224 (UniProtKB)
Alt. Names/Synonyms: DKFZp586H0723; GTP-binding protein smg p21B; K-REV; RAL1B; RAP1B; RAP1B, member of RAS oncogene family; Ras family small GTP binding protein RAP1B; Ras-related protein Rap-1b; RAS-related protein RAP1B; small GTP binding protein
Gene Symbols: RAP1B
Molecular weight: 20,825 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene