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CGA
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. Belongs to the glycoprotein hormones subunit alpha family. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
| Chromosomal Location of Human Ortholog: 6q14.3 |
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Cellular Component:
extracellular region; extracellular space; follicle-stimulating hormone complex; Golgi lumen
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Molecular Function:
follicle-stimulating hormone activity; hormone activity; protein binding
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Biological Process:
G protein-coupled receptor signaling pathway; peptide hormone processing; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of steroid biosynthetic process; positive regulation of transcription by RNA polymerase II; regulation of signaling receptor activity; regulation of transcription by RNA polymerase II
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Reference #:
P01215
(UniProtKB)
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Alt. Names/Synonyms: Anterior pituitary glycoprotein hormones common subunit alpha; CG-alpha; CGA; Choriogonadotropin alpha chain; Chorionic gonadotrophin subunit alpha; chorionic gonadotropin, alpha polypeptide; Follicle-stimulating hormone alpha chain; follicle-stimulating hormone alpha subunit; Follitropin alpha chain; FSH-alpha; FSHA; GLHA; Glycoprotein hormones alpha chain; glycoprotein hormones, alpha polypeptide; GPHa; GPHA1; HCG; LHA; LSH-alpha; Luteinizing hormone alpha chain; Lutropin alpha chain; Thyroid-stimulating hormone alpha chain; Thyrotropin alpha chain; TSH-alpha; TSHA
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Gene Symbols: CGA
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Molecular weight:
13,075 Da
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Basal Isoelectric point:
8.54
Predict pI for various phosphorylation states
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