CGA Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. Belongs to the glycoprotein hormones subunit alpha family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 6q14.3
Cellular Component:  extracellular region; extracellular space; follicle-stimulating hormone complex; Golgi lumen; pituitary gonadotropin complex
Molecular Function:  follicle-stimulating hormone activity; hormone activity; protein binding
Biological Process:  follicle-stimulating hormone secretion; follicle-stimulating hormone signaling pathway; G protein-coupled receptor signaling pathway; hormone-mediated signaling pathway; luteinizing hormone secretion; negative regulation of organ growth; organ growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of steroid biosynthetic process; positive regulation of transcription by RNA polymerase II; regulation of signaling receptor activity; thyroid gland development; thyroid hormone generation
Reference #:  P01215 (UniProtKB)
Alt. Names/Synonyms: Anterior pituitary glycoprotein hormones common subunit alpha; CG-alpha; CGA; Choriogonadotropin alpha chain; Chorionic gonadotrophin subunit alpha; chorionic gonadotropin, alpha polypeptide; Follicle-stimulating hormone alpha chain; follicle-stimulating hormone alpha subunit; Follitropin alpha chain; FSH-alpha; FSHA; GLHA; Glycoprotein hormones alpha chain; glycoprotein hormones, alpha polypeptide; GPA1; GPHa; GPHA1; HCG; LHA; LSH-alpha; Luteinizing hormone alpha chain; Lutropin alpha chain; Thyroid-stimulating hormone alpha chain; Thyrotropin alpha chain; TSH-alpha; TSHA
Gene Symbols: CGA
Molecular weight: 13,075 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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