|
CGA
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. Belongs to the glycoprotein hormones subunit alpha family. Note: This description may include information from UniProtKB.
|
| Protein type: Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 6q14.3 |
|
Cellular Component:
extracellular region; extracellular space; follicle-stimulating hormone complex; Golgi lumen; pituitary gonadotropin complex
|
|
Molecular Function:
follicle-stimulating hormone activity; hormone activity; protein binding
|
|
Biological Process:
follicle-stimulating hormone secretion; follicle-stimulating hormone signaling pathway; G protein-coupled receptor signaling pathway; hormone-mediated signaling pathway; luteinizing hormone secretion; negative regulation of organ growth; organ growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of steroid biosynthetic process; positive regulation of transcription by RNA polymerase II; regulation of signaling receptor activity; thyroid gland development; thyroid hormone generation
|
|
Reference #:
P01215
(UniProtKB)
|
|
Alt. Names/Synonyms: Anterior pituitary glycoprotein hormones common subunit alpha; CG-alpha; CGA; Choriogonadotropin alpha chain; Chorionic gonadotrophin subunit alpha; chorionic gonadotropin, alpha polypeptide; Follicle-stimulating hormone alpha chain; follicle-stimulating hormone alpha subunit; Follitropin alpha chain; FSH-alpha; FSHA; GLHA; Glycoprotein hormones alpha chain; glycoprotein hormones, alpha polypeptide; GPA1; GPHa; GPHA1; HCG; LHA; LSH-alpha; Luteinizing hormone alpha chain; Lutropin alpha chain; Thyroid-stimulating hormone alpha chain; Thyrotropin alpha chain; TSH-alpha; TSHA
|
|
Gene Symbols: CGA
|
|
Molecular weight:
13,075 Da
|
|
Basal Isoelectric point:
8.54
Predict pI for various phosphorylation states
|
