EIF2A Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. Belongs to the WD repeat EIF2A family. Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Translation
Chromosomal Location of human Ortholog: 3q25.1
Cellular Component:  cytoplasm; cytosolic small ribosomal subunit; eukaryotic translation initiation factor 2 complex
Molecular Function:  mRNA binding; protein binding; ribosome binding; translation initiation factor activity; tRNA binding
Biological Process:  positive regulation of signal transduction; protein phosphorylation; regulation of translation; response to amino acid starvation; ribosome assembly; SREBP signaling pathway; translational initiation
Reference #:  Q9BY44 (UniProtKB)
Alt. Names/Synonyms: 65 kDa eukaryotic translation initiation factor 2A; CDA02; eIF-2A; EIF2A; Eukaryotic translation initiation factor 2A; eukaryotic translation initiation factor 2A, 65kDa; Eukaryotic translation initiation factor 2A, N-terminally processed; MST089; MSTP004; MSTP089
Gene Symbols: EIF2A
Molecular weight: 64,990 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein