|
EIF2A
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. Belongs to the WD repeat EIF2A family. Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Translation |
| Chromosomal Location of Human Ortholog: 3q25.1 |
|
Cellular Component:
cytoplasm; eukaryotic translation initiation factor 2 complex
|
|
Molecular Function:
protein binding; ribosome binding; translation initiation factor activity; tRNA binding
|
|
Biological Process:
positive regulation of signal transduction; protein phosphorylation; regulation of translation; response to amino acid starvation; ribosome assembly; SREBP signaling pathway; translational initiation
|
|
Reference #:
Q9BY44
(UniProtKB)
|
|
Alt. Names/Synonyms: 65 kDa eukaryotic translation initiation factor 2A; CDA02; eIF-2A; EIF2A; Eukaryotic translation initiation factor 2A; eukaryotic translation initiation factor 2A, 65kDa; MST089; MSTP004; MSTP089
|
|
Gene Symbols: EIF2A
|
|
Molecular weight:
64,990 Da
|
|
Basal Isoelectric point:
9.01
Predict pI for various phosphorylation states
|
