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EIF2A
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. Belongs to the WD repeat EIF2A family. Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Translation |
| Chromosomal Location of human Ortholog: 3q25.1 |
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Cellular Component:
cytoplasm; cytosolic small ribosomal subunit; eukaryotic translation initiation factor 2 complex
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Molecular Function:
mRNA binding; protein binding; ribosome binding; translation initiation factor activity; tRNA binding
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Biological Process:
positive regulation of signal transduction; protein phosphorylation; regulation of translation; response to amino acid starvation; ribosome assembly; SREBP signaling pathway; translational initiation
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Reference #:
Q9BY44
(UniProtKB)
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Alt. Names/Synonyms: 65 kDa eukaryotic translation initiation factor 2A; CDA02; eIF-2A; EIF2A; Eukaryotic translation initiation factor 2A; eukaryotic translation initiation factor 2A, 65kDa; Eukaryotic translation initiation factor 2A, N-terminally processed; MST089; MSTP004; MSTP089
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Gene Symbols: EIF2A
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Molecular weight:
64,990 Da
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Basal Isoelectric point:
9.01
Predict pI for various phosphorylation states
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