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ZNF462
Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA. Regulates neuronal development and neural cell differentiation. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein |
| Chromosomal Location of human Ortholog: 9q31.2 |
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Cellular Component:
nucleoplasm; nucleus
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Molecular Function:
DNA binding; metal ion binding; protein binding
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Biological Process:
chromatin organization; negative regulation of DNA binding; positive regulation of transcription by RNA polymerase II
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Disease: Weiss-kruszka Syndrome
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Reference #:
Q96JM2
(UniProtKB)
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Alt. Names/Synonyms: DKFZp686B2325; DKFZp762N2316; FLJ14960; FLJ45904; KIAA1803; RP11-508N12.1; WSKA; Zfp462; ZFPIP; Zinc finger PBX1-interacting protein; Zinc finger protein 462; ZN462; ZNF462
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Gene Symbols: ZNF462
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Molecular weight:
284,688 Da
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Basal Isoelectric point:
7.53
Predict pI for various phosphorylation states
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