BAG3 Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Chaperone
Chromosomal Location of Human Ortholog: 10q26.11
Cellular Component:  aggresome; chaperone complex; cytoplasm; cytosol; neuron projection; nucleus; plasma membrane; stress fiber; Z disc
Molecular Function:  adenyl-nucleotide exchange factor activity; chaperone binding; dynein intermediate chain binding; protein binding; protein-containing complex binding
Biological Process:  aggresome assembly; autophagosome assembly; brain development; cellular response to heat; cellular response to mechanical stimulus; cellular response to unfolded protein; chaperone-mediated autophagy; chaperone-mediated protein transport; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; muscle cell cellular homeostasis; negative regulation of apoptotic process; negative regulation of protein targeting to mitochondrion; negative regulation of striated muscle cell apoptotic process; negative regulation of transcription from RNA polymerase II promoter in response to stress; positive regulation of aggrephagy; positive regulation of protein export from nucleus; positive regulation of protein import into nucleus; protein folding; protein stabilization; protein transport along microtubule; regulation of catalytic activity; regulation of cellular response to heat; spinal cord development
Disease: Cardiomyopathy, Dilated, 1hh; Myopathy, Myofibrillar, 6
Reference #:  O95817 (UniProtKB)
Alt. Names/Synonyms: BAG family molecular chaperone regulator 3; BAG-3; BAG-family molecular chaperone regulator-3; BAG3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; BCL2-associated athanogene 3; BCL2-binding athanogene 3; BIS; CAIR-1; Docking protein CAIR-1; MGC104307
Gene Symbols: BAG3
Molecular weight: 61,595 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene