Vimentin Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Belongs to the intermediate filament family. Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Cellular Component:  cell leading edge; cytoplasm; cytosol; intermediate filament; neuron projection; nuclear matrix; nucleus; peroxisome; phagocytic vesicle; plasma membrane; polysome
Molecular Function:  double-stranded RNA binding; identical protein binding; keratin filament binding; protein binding; protein domain specific binding; scaffold protein binding; structural constituent of cytoskeleton; structural constituent of eye lens
Biological Process:  astrocyte development; Bergmann glial cell differentiation; cellular response to interferon-gamma; cellular response to lipopolysaccharide; cellular response to muramyl dipeptide; in utero embryonic development; intermediate filament organization; lens fiber cell development; negative regulation of neuron projection development; positive regulation of collagen biosynthetic process; positive regulation of superoxide anion generation; positive regulation of translation; regulation of mRNA stability; SMAD protein signal transduction
Reference #:  P48616 (UniProtKB)
Alt. Names/Synonyms: VIM; VIME; Vimentin
Gene Symbols: VIM
Molecular weight: 53,728 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
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Vimentin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein