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IGFBP3
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Expressed by most tissues. Present in plasma. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide |
| Chromosomal Location of mouse Ortholog: 11 A1|11 4.75 cM |
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Cellular Component:
extracellular region; extracellular space; insulin-like growth factor binary complex; insulin-like growth factor ternary complex; nuclear heterochromatin; nucleus; platelet alpha granule
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Molecular Function:
fibronectin binding; growth factor binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; protein tyrosine phosphatase activator activity
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Biological Process:
negative regulation of cell proliferation; negative regulation of protein phosphorylation; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; negative regulation of testosterone secretion; osteoblast differentiation; positive regulation of apoptotic DNA fragmentation; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of myoblast differentiation; protein phosphorylation; regulation of cell growth; regulation of glucose metabolic process; regulation of growth; regulation of insulin-like growth factor receptor signaling pathway; type B pancreatic cell proliferation
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Reference #:
P47878
(UniProtKB)
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Alt. Names/Synonyms: AI649005; IBP-3; IBP3; IGF-binding protein 3; IGFBP; IGFBP-3; Igfbp3; IGgfbp3; insulin-like growth factor binding protein 3; Insulin-like growth factor-binding protein 3; OTTMUSP00000005343
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Gene Symbols: Igfbp3
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Molecular weight:
31,687 Da
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Basal Isoelectric point:
8.76
Predict pI for various phosphorylation states
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