VTN Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. Plasma. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of mouse Ortholog: 11 B5|11 46.74 cM
Cellular Component:  basement membrane; collagen-containing extracellular matrix; cytoplasm; endoplasmic reticulum; extracellular matrix; extracellular region; extracellular space; Golgi lumen; intracellular membrane-bounded organelle; rough endoplasmic reticulum lumen
Molecular Function:  collagen binding; extracellular matrix binding; extracellular matrix structural constituent; heparin binding; identical protein binding; integrin binding; polysaccharide binding; scavenger receptor activity
Biological Process:  cell adhesion; cell adhesion mediated by integrin; cell migration; cell proliferation; cell-matrix adhesion; endodermal cell differentiation; extracellular matrix organization; immune response; liver regeneration; negative regulation of endopeptidase activity; oligodendrocyte differentiation; positive regulation of cell-substrate adhesion; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein binding; positive regulation of receptor-mediated endocytosis; positive regulation of smooth muscle cell migration; protein polymerization; smooth muscle cell-matrix adhesion
Reference #:  P29788 (UniProtKB)
Alt. Names/Synonyms: AI256434; OTTMUSP00000000198; S-protein; Serum-spreading factor; Vitronectin; Vn; Vtn; VTNC
Gene Symbols: Vtn
Molecular weight: 54,849 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene