GLP1R G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. Belongs to the G-protein coupled receptor 2 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 17 A3.3|17 15.8 cM
Cellular Component:  integral component of membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function:  G protein-coupled peptide receptor activity; G protein-coupled receptor activity; glucagon receptor activity; glucagon-like peptide 1 receptor activity; peptide hormone binding; peptide receptor activity; signaling receptor activity; transmembrane signaling receptor activity
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; associative learning; cAMP-mediated signaling; cell surface receptor signaling pathway; feeding behavior; hormone secretion; insulin secretion; learning or memory; memory; negative regulation of apoptotic process; negative regulation of neuron apoptotic process; neuropeptide signaling pathway; positive regulation of blood pressure; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of cytosolic calcium ion concentration; positive regulation of heart contraction; positive regulation of insulin secretion; positive regulation of transcription by RNA polymerase II; regulation of calcium ion transport; regulation of heart contraction; release of sequestered calcium ion into cytosol; response to glucose; response to psychosocial stress; signal transduction
Reference #:  O35659 (UniProtKB)
Alt. Names/Synonyms: GLP-1 receptor; GLP-1-R; GLP-1R; Glp1r; GLP1Rc; Glucagon-like peptide 1 receptor
Gene Symbols: Glp1r
Molecular weight: 53,028 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
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GLP1R

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene