LRRFIP1 Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Belongs to the LRRFIP family. Ubiquitously expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; RNA-binding
Chromosomal Location of human Ortholog: 2q37.3
Cellular Component:  cytoplasm; cytoskeleton; cytosol; nucleus; plasma membrane
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded RNA binding; protein binding; protein homodimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of NF-kappaB transcription factor activity; positive regulation of type I interferon production; regulation of transcription by RNA polymerase II
Reference #:  Q32MZ4 (UniProtKB)
Alt. Names/Synonyms: FLAP-1; FLAP1; FLIIAP1; GC-binding factor 2; GCF-2; GCF2; HUFI-1; leucine rich repeat (in FLII) interacting protein 1; Leucine-rich repeat flightless-interacting protein 1; LRR binding FLII interacting protein 1; LRR FLII-interacting protein 1; LRRF1; LRRFIP1; MGC10947; MGC119738; MGC119739; NEDD8-conjugating enzyme; TAR RNA-interacting protein; transcription factor 9-like; TRIP
Gene Symbols: LRRFIP1
Molecular weight: 89,253 Da
Basal Isoelectric point: 4.59  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein