PTDSS1 Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine. Belongs to the phosphatidyl serine synthase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transferase
Chromosomal Location of human Ortholog: 8q22.1
Cellular Component:  endoplasmic reticulum membrane; integral component of membrane; membrane
Molecular Function:  transferase activity
Biological Process:  phosphatidylserine biosynthetic process
Disease: Lenz-majewski Hyperostotic Dwarfism
Reference #:  P48651 (UniProtKB)
Alt. Names/Synonyms: KIAA0024; LMHD; Phosphatidylserine synthase 1; PSS-1; PSS1; PSSA; PtdSer synthase 1; PTDSS1; PTSS1; Serine-exchange enzyme I
Gene Symbols: PTDSS1
Molecular weight: 55,528 Da
Basal Isoelectric point: 8.71  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene