FCER1G Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation. Belongs to the CD3Z/FCER1G family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component:  cell surface; ficolin-1-rich granule membrane; integral component of plasma membrane; plasma membrane; tertiary granule membrane
Molecular Function:  protein binding; protein homodimerization activity
Biological Process:  blood coagulation; cellular response to low-density lipoprotein particle stimulus; Fc-epsilon receptor signaling pathway; integrin-mediated signaling pathway; interleukin-2 production; interleukin-3-mediated signaling pathway; leukocyte migration; mast cell activation; negative regulation of mast cell apoptotic process; neutrophil degranulation; osteoclast differentiation; phagocytosis, engulfment; platelet activation; positive regulation of interleukin-10 production; positive regulation of interleukin-4 production; positive regulation of interleukin-6 production; positive regulation of mast cell cytokine production; positive regulation of mast cell degranulation; positive regulation of protein localization to cell surface; positive regulation of tumor necrosis factor production; positive regulation of type I hypersensitivity; positive regulation of type IIa hypersensitivity; positive regulation of type III hypersensitivity; protein homooligomerization; protein localization to plasma membrane; receptor internalization; serotonin secretion by platelet; stimulatory C-type lectin receptor signaling pathway
Reference #:  P30273 (UniProtKB)
Alt. Names/Synonyms: Fc epsilon receptor Ig; Fc fragment of IgE receptor Ig; Fc fragment of IgE, high affinity I, receptor for; Fc receptor gamma-chain; Fc-epsilon RI-gamma; FCER1G; FCERG; FceRI gamma; FCRG; FcRgamma; gamma polypeptide; High affinity immunoglobulin epsilon receptor subunit gamma; IgE Fc receptor subunit gamma; immunoglobulin E receptor, high affinity, gamma chain
Gene Symbols: FCER1G
Molecular weight: 9,667 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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FCER1G

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene