FCER1G
Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation. Belongs to the CD3Z/FCER1G family. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral; Receptor, misc. |
Chromosomal Location of human Ortholog: 1q23.3 |
Cellular Component:
cell surface; external side of plasma membrane; Fc-epsilon receptor I complex; Fc-gamma receptor III complex; ficolin-1-rich granule membrane; plasma membrane; tertiary granule membrane
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Molecular Function:
identical protein binding; IgE binding; IgE receptor activity; IgG binding; protein binding; protein homodimerization activity
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Biological Process:
antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class II; cellular response to low-density lipoprotein particle stimulus; defense response to bacterium; Fc receptor mediated stimulatory signaling pathway; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway; immunoglobulin mediated immune response; innate immune response; interleukin-3-mediated signaling pathway; neutrophil activation involved in immune response; neutrophil chemotaxis; positive regulation of interleukin-4 production; positive regulation of phagocytosis; receptor internalization; regulation of platelet activation; T cell differentiation involved in immune response
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Reference #:
P30273
(UniProtKB)
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Alt. Names/Synonyms: Fc epsilon receptor Ig; Fc fragment of IgE receptor Ig; Fc fragment of IgE, high affinity I, receptor for; Fc receptor gamma-chain; Fc-epsilon RI-gamma; FCER1G; FCERG; FceRI gamma; FCRG; FcRgamma; gamma polypeptide; High affinity immunoglobulin epsilon receptor subunit gamma; IgE Fc receptor subunit gamma; immunoglobulin E receptor, high affinity, gamma chain
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Gene Symbols: FCER1G
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Molecular weight:
9,667 Da
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Basal Isoelectric point:
6.54
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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