COPB1 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis. Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 11p15.2
Cellular Component:  COPI vesicle coat; cytosol; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; ficolin-1-rich granule membrane; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; intracellular membrane-bounded organelle; plasma membrane; secretory granule membrane; tertiary granule membrane; transport vesicle
Molecular Function:  protein binding; structural molecule activity
Biological Process:  ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; intracellular protein transport; neutrophil degranulation; retrograde vesicle-mediated transport, Golgi to ER; viral process
Reference #:  P53618 (UniProtKB)
Alt. Names/Synonyms: beta coat protein; Beta-coat protein; Beta-COP; coatomer protein complex subunit beta 1; coatomer protein complex, subunit beta 1; Coatomer subunit beta; COPB; COPB1; COPI coat complex subunit beta 1; DKFZp761K102; FLJ10341; FLJ46444; FLJ57957
Gene Symbols: COPB1
Molecular weight: 107,142 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein