p63 Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. Belongs to the p53 family. Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. 2 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of rat Ortholog: 11q22
Cellular Component:  chromatin; cytoplasm; dendrite; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  chromatin binding; damaged DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; p53 binding; protein domain specific binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; WW domain binding
Biological Process:  anatomical structure formation involved in morphogenesis; animal organ morphogenesis; apoptotic process; cellular senescence; chromatin remodeling; cloacal septation; cranial skeletal system development; determination of adult lifespan; DNA damage response; ectoderm and mesoderm interaction; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; epidermal cell differentiation; epidermal cell division; epidermis development; epithelial cell apoptotic process; epithelial cell development; epithelial cell differentiation; establishment of planar polarity; establishment of skin barrier; female genitalia morphogenesis; female gonad development; hair follicle development; hair follicle morphogenesis; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; keratinocyte development; keratinocyte differentiation; keratinocyte proliferation; morphogenesis of a polarized epithelium; negative regulation of cellular senescence; negative regulation of DNA-templated transcription; negative regulation of epithelial cell apoptotic process; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of keratinocyte differentiation; negative regulation of mesoderm development; negative regulation of transcription by RNA polymerase II; neuron apoptotic process; Notch signaling pathway; odontogenesis of dentin-containing tooth; pattern specification process; polarized epithelial cell differentiation; positive regulation of apoptotic signaling pathway; positive regulation of cell cycle G1/S phase transition; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of fibroblast apoptotic process; positive regulation of keratinocyte proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of somatic stem cell population maintenance; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; post-anal tail morphogenesis; prostate gland development; prostatic bud formation; protein tetramerization; proximal/distal pattern formation; regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of DNA-templated transcription; regulation of epidermal cell division; regulation of transcription by RNA polymerase II; skeletal system development; skin epidermis development; skin morphogenesis; smooth muscle tissue development; spermatogenesis; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; stem cell differentiation; stem cell proliferation; sympathetic nervous system development; transcription by RNA polymerase II; urinary bladder development
Reference #:  Q9JJP6 (UniProtKB)
Alt. Names/Synonyms: Keratinocyte transcription factor KET; Ket; P63; p73L; TP63; Tp73l; transformation related protein 63; Transformation-related protein 63; Trp63; Tumor protein 63; tumor protein 63 kDa; tumor protein p63; Tumor protein p73-like
Gene Symbols: Tp63
Molecular weight: 76,760 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene