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prolactin
Prolactin acts primarily on the mammary gland by promoting lactation. Belongs to the somatotropin/prolactin family. Note: This description may include information from UniProtKB.
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| Protein type: Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide |
| Chromosomal Location of rat Ortholog: 17p12 |
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Cellular Component:
extracellular region; extracellular space; secretory granule
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Molecular Function:
hormone activity; metal ion binding; prolactin receptor binding
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Biological Process:
cell population proliferation; cellular response to hormone stimulus; cellular response to hypoxia; circadian rhythm; epithelial cell proliferation; female pregnancy; lactation; mammary gland development; maternal behavior; multicellular organismal response to stress; negative regulation of endothelial cell proliferation; negative regulation of estrogen biosynthetic process; negative regulation of hydrogen peroxide biosynthetic process; negative regulation of nitric oxide biosynthetic process; negative regulation of progesterone biosynthetic process; ovulation cycle; parturition; positive regulation of cell population proliferation; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of lactation; positive regulation of miRNA transcription; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of vascular endothelial growth factor production; regulation of ossification; regulation of receptor signaling pathway via JAK-STAT; response to estradiol; response to ethanol; response to lipopolysaccharide; response to macrophage colony-stimulating factor; response to nutrient; response to nutrient levels; response to organic cyclic compound; response to xenobiotic stimulus; signal transduction
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Reference #:
P01237
(UniProtKB)
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Alt. Names/Synonyms: PRL; Prl1a1; PRLB; PRLSD1; Prol; Prolactin; prolactin family 1, subfamily a, member 1; RATPRLSD1; RNPROL
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Gene Symbols: Prl
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Molecular weight:
25,753 Da
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Basal Isoelectric point:
5.39
Predict pI for various phosphorylation states
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